Cytotoxic T Lymphocytes and Vaccine Development 2013
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منابع مشابه
Cytotoxic T Lymphocytes and Vaccine Development 2013
CTLs play a critical role in �ghting chronic virus infection and cancers. Despite the tremendous efforts spent so far, generating potent and highly effective CTLs remain a major roadblock for disease control (prevention and therapies). Activation of CTLs requires different stimuli and is in�uenced by different disease conditions. In this special issue, several papers investigated functions of c...
متن کاملCytotoxic T Lymphocytes and Vaccine Development
Along with the development of new technology, the molecular mechanisms of the generation of functional CTLs have been elucidated over the last several years which together will undoubtedly enhance our progression towards the development of successful vaccines for the many chronic viral infections and cancer. It has been shown that the activation of naı̈ve CTLs requires all three signals to be fu...
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Research on CTLs has been booming in recent years—there are more than 250 papers related to CD8 T-cells published everymonth.With such rapid advancement in this particular aspect of immunology alone, it is important to summarize and report information on this hot topic in a timely and organized fashion. Although the submission window for this issue was open for a significantly shorter period co...
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Immune responses of cytotoxic T lymphocytes (CTLs) are implicated in viral eradication and the pathogenesis of hepatitis C. Weak CTL response against hepatitis C virus (HCV) may lead to a persistent infection. HCV infection impairs the function of HCV-specific CTLs; HCV proteins are thought to actively suppress host immune responses, including CTLs. Induction of a strong HCV-specific CTL respon...
متن کاملCytotoxic T lymphocytes
Cancer stem cells (CSCs)/cancer-initiating cells (CICs) are characterized as a small population of cancer cells that have high tumor-initiating ability. CSCs/CICs are resistant to several cancer therapies, and eradication of CSCs/CICs is essential to cure cancer. How can we eradicate CSCs/CICs? Cytotoxic T lymphocytes (CTLs) might be a promising answer.
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ژورنال
عنوان ژورنال: BioMed Research International
سال: 2013
ISSN: 2314-6133,2314-6141
DOI: 10.1155/2013/865314